Semaglutide vs. Tirzepatide: Comparison Chart

Semaglutide FAQ

What is semaglutide?
Semaglutide is a GLP-1 receptor agonist — a type of medication that helps regulate appetite, reduce cravings, slow digestion, and support healthy blood sugar levels. It was originally approved by the FDA for type 2 diabetes and is now also approved for weight management in eligible patients.

How does it work for weight loss?
Semaglutide works with your body’s natural hormones to help you feel full longer, reduce hunger, and decrease overeating. Many people find it easier to follow healthier eating habits and achieve sustainable weight loss while on treatment.

What does treatment look like?
We begin with an initial consultation to make sure semaglutide is safe and appropriate for you. If you’re a candidate, you’ll receive weekly injections, usually in bundles of four. We’ll check in with you regularly to monitor your progress, answer your questions, and adjust treatment if needed.

Who is a good candidate?
Semaglutide may be right for adults who:

• Have a BMI in the overweight or obese range

• Struggle with appetite control or cravings

• Want medical support with their weight management goals

• Do not have certain medical conditions (your provider will review these at your consult)

Are there side effects?
The most common side effects are mild digestive symptoms such as nausea, constipation, diarrhea, or stomach discomfort. These often improve as your body adjusts. Rare but serious risks (such as pancreatitis or gallbladder issues) will be discussed at your consultation so you can make an informed decision.

Do I need to diet or exercise while taking semaglutide?
Semaglutide works best when combined with healthy lifestyle choices. We’ll provide guidance on nutrition, movement, and self-care strategies to help you get the best results.

When will I see results?
Everyone is different. Some people notice changes within the first month, while for others, progress is more gradual. Consistency with your injections and lifestyle habits makes the biggest difference.

Is semaglutide safe?
For the right patient, semaglutide can be safe and effective. That’s why we start with a thorough consultation to review your health history, medications, and possible contraindications before beginning treatment.

What to expect:
In clinical studies, patients using semaglutide alongside healthy lifestyle changes lost an average of 15% of their body weight over time, with many noticing improvements in energy, appetite control, and overall well-being within the first few months. While individual results vary, semaglutide has shown to be one of the most effective tools currently available for medical weight management.

Tirzepatide FAQ

What is tirzepatide?

Tirzepatide is a once-weekly injectable medication that works on two key metabolic pathways—GLP-1 and GIP—to help regulate appetite, improve insulin sensitivity, and support significant weight loss.

How does tirzepatide help with weight management?

It reduces hunger, slows stomach emptying, improves fullness, and helps balance blood sugar levels. The dual-hormone action often leads to stronger appetite control and faster results compared to traditional GLP-1 medications.

Who is a good candidate for tirzepatide?

Tirzepatide may be appropriate for adults looking to improve metabolic health or support weight loss—especially those struggling with cravings, insulin resistance, or difficulty losing weight with diet and exercise alone. A medical consultation is required to determine eligibility.

How often do I take tirzepatide?

It is administered once weekly. Your dose may be gradually adjusted over time to minimize side effects and optimize results.

Can I self-inject at home?

Yes. Most patients self-administer their weekly injection. During your consultation, we provide step-by-step instruction on safe injection technique and dosage.

How soon will I see results?

Many patients begin to notice appetite reduction within the first 1–2 weeks. Weight loss typically becomes more noticeable after several weeks, with continued progress as the dose increases and lifestyle habits align.

What are the common side effects?

The most common effects are mild and include nausea, fullness, constipation, or fatigue. These usually improve as your body adjusts to the medication.

Is tirzepatide safe?

Tirzepatide is FDA-approved for diabetes management and is widely used off-label for weight loss under medical supervision.

Will I need to follow a specific diet?

There is no strict diet required, but we encourage balanced meals, adequate hydration, protein intake, and mindful portion control to support your results and minimize side effects.

What happens during my initial visit?

Your Nurse Practitioner will review your medical history, medications, and goals to determine if tirzepatide is appropriate. If approved, you’ll receive the medication, dose instructions, and ongoing support.

How long do I need to stay on tirzepatide?

Duration varies. Many patients stay on medication for several months to achieve desired results and then transition to a maintenance plan. We tailor this timeline to your goals and your body’s response.